DOPAMINE D1A RECEPTOR REGULATION OF PHOSPHOLIPASE C (PLC) ISOFORM EXPRESSION. • 2219

Dopamine D1A receptor regulation of phospholipase C isoform.

In LTK- cells stably transfected with rat D1A receptor cDNA, fenoldopam, a D1 agonist, increased phosphatidylinositol 4, 5-bisphosphate hydrolysis in a time-dependent manner. In the cytosol, phospholipase C (PLC) activity increased (50 +/- 7%) in 30 s, returned to basal level at 4 h, and decreased below basal values by 24 h; in the membrane, PLC activity also increased (36 +/- 13%) in 30 s, ret...

Cbl Suppresses B Cell Receptor–Mediated Phospholipase C (Plc)-γ2 Activation by Regulating B Cell Linker Protein–Plc-γ2 Binding

Accumulating evidence indicates that the Cbl protein plays a negative role in immune receptor signaling; however, the mode of Cbl action in B cell receptor (BCR) signaling still remains unclear. DT40 B cells deficient in Cbl showed enhanced BCR-mediated phospholipase C (PLC)-gamma2 activation, thereby leading to increased apoptosis. A possible explanation for the involvement of Cbl in PLC-gamma...

HIP-70: an isoform of phosphoinositol-specific phospholipase C-alpha.

Biology of Free Radicals D5 dopamine receptor regulation of phospholipase D

Zhiwei Yang, Laureano D. Asico, Peiying Yu, Zheng Wang, John E. Jones, Ren-kui Bai, David R. Sibley, Robin A. Felder, and Pedro A. Jose Department of Physiology and Biophysics, Department of Pediatrics, Institute for Molecular and Human Genetics, Georgetown University Medical Center, Washington, District of Columbia; National Institute Neurological Disorders and Stroke, Bethesda, Maryland; and ...

Selective inhibition of the renal dopamine subtype D1A receptor induces antinatriuresis in conscious rats.

Both dopamine D1-like (D1A and D1B) and D2-like (D2, D3, and D4) receptor subfamilies are present in the kidney. Blockade of the intrarenal D1-like receptor family is associated with natriuresis and diuresis. Because the D1A and D1B receptor subtypes are not distinguishable by currently available dopaminergic agents, their functional role remains undefined. In the present study, the effect of s...